MrBaoming Wang

My research focuses on the molecular and translational mechanisms by which environmental exposures contribute to human disease, with particular expertise in particulate matter (PM2.5), extracellular vesicle (EV) biology, and next-generation sequencing (NGS)-based cancer diagnostics. My work is centred around three interconnected areas.

First, I investigate the health effects of PM2.5 exposure using both in vitro and in vivo models, with a particular emphasis on environmentally relevant exposure levels in Australia. My research was among the first to demonstrate that PM2.5 at Australian ambient levels remains harmful to health, highlighting that even comparatively low-level exposure should not be assumed safe. This work provides important experimental evidence supporting the concept that there may be no truly safe threshold for PM2.5 exposure.

Second, I am interested in the intersection between PM2.5 exposure and extracellular vesicles (EVs). I explore how PM2.5 alters EV production, cargo, and biological function, and how these EV-mediated signals contribute to tissue injury, inflammation, and disease progression, including cancer metastasis. This line of research aims to uncover mechanistic links between environmental stress and intercellular communication.

Third, I have a strong interest in cancer diagnosis using next-generation sequencing (NGS). My work in this area focuses on the development and application of NGS-based diagnostic approaches to improve molecular classification, biomarker detection, and clinically relevant decision-making in cancer. This translational experience complements my mechanistic research by linking molecular discovery with real-world clinical utility.